Services

CellSight provides customized expert molecular imaging services for monitoring cell kinetics and gene expression in research animals and humans. We employ non-invasive molecular genetic imaging as well as in vitro detection techniques.

Cell Kinetics Services Offered

  • Monitor pharmacokinetics of therapeutic cells in living subjects (research animals and humans) at multiple desired time-points following administration. Client therapeutic cells can vary
    • Therapeutic immune cells (NK, T Cells, DCs, Macrophages)
    • Stem cells (Messenchymal, Embryonic, iPS, Adult Stem Cells)
    • Other therapeutic cells (Pancreatic islets, etc...)
  • Track changes in transplanted tissues at multiple desired time points:
    • Survival of tissue cells
    • Changes in characteristics of tissue cells
    • Migration of tissue cells
    • Proliferation of tissue cells
  • Analyze effect of drugs on cells:
    • Cell killing by a therapeutic agent
    • Cell growth/proliferation induced by a therapeutic agent
    • Therapeutic agent causing cell migration or inhibiting cell migration
    • Therapeutic agent causing a change in cell characteristics (e.g. differentiation)

Gene Expression Services Offered

  • Evaluate pharmacokinetics of therapeutic transgenes including magnitude of therapeutic transgene expression at each location
  • Monitor endogenous gene expression and effect of external factors on the expression

Custom Services Offered

  • Genetically engineer cells to express one or more imaging reporter genes of different modalities
  • Assay cells or tissues for imaging reporter gene expression
  • Pre-label cells with imaging probes
  • Pre-clinical and clinical pharmacokinetic analysis of therapeutic cells
  • Pre-clinical and clinical reporter gene imaging studies
  • Monitor cell and gene therapy through molecular imaging
  • Monitor cancer therapy efficacy through reporter gene imaging or general molecular imaging
  • Pre-clinical and clinical molecular imaging consulting

Products